So apparently Ifosfamide (a chemotherapy drug) has a unique side effect of causing "altered mental status" aside from the standard "chemo-brain" that patients on chemotherapy get. This altered mental status can lead
to all sorts of symptoms one of which being hallucinations another of
which, as our nurse practitioner told us today, is peeing in the corner of your hospital room. So if Ben pees in the corner, we are supposed to tell the doctors. ;) Haha. Hopefully this won't happen since he is being prophylactically (preventatively) treated with Thiamine, a B vitamin.
Vitamin B1 or Thiamine is used as both treatment and prevention for encephalopathy (disease of the brain). The pathophysiological mechanism (how ifosfamide causes this disease) is unknown. Being a water-soluble vitamin, the body will take as much as it needs to function and fill its stores and then you will pee off the rest making this a generally safe vitamin that won't accumulate and cause toxicity. [1]
So, this goes to show that vitamins are extremely important. Probably more important than most people realize; however, they can definitely be over-used and cause toxicity if not used appropriately. It's about balance.
Cool Fact:
The word "Vitamin" came about while Thiamine was being discovered and named.
In Latin, “vita” = life and “amine” =
nitrogen-containing compound.
Cool. Now you know.
So, back to the Bs.
First, an overview.
Each of these vitamins has a unique function but in general the B vitamins support metabolism, the immune system, the nervous system and cell growth. All are water soluble (meaning you will pee any unused and unstored vitamin out).
Out of all of these B vitamins, there is one that I want to discuss particularly with regards to nutrition.
Let's talk B12. [2]
"Why this one?", you ask.
This little vitamin is the main reason why I am not sure a strict vegan diet is what our bodies should optimally be eating for the greatest health. You see, B12 is
only found naturally in animal products.
No plant has ever been shown to have vitamin B12 unless it has been contaminated by animal waste or bacteria in soil, like manure.
But wait just a second.... aren't we animals?
Shouldn't we be able to make B12 if other animal species can make it?
Good
question. Animals don't actually make the B12. It is
synthesized by a variety of anaerobic organisms in the gut using cobalt from the food in the pasture. Many animals can absorb this straight from their gut but humans and some other species can only absorb vitamin B12 in one part of their intestines, which happens to be before the area where the B12 gets produced therefor the B12 just gets excreted in the body's waste products. As unappetizing as it sounds, other species preserve their B12 by eating their own feces..... somehow I don't expect that option to be sweeping the nation for vegans.
So, yes, we already have B12 in our gut but our body is not efficient at absorbing it.
So really the B12 options are:
1- Eat meat (preferably seafood as you will see) or
2- Eat fortified foods or supplements
So how much Vitamin B12 do I really need? [2]
Not a lot actually.
It is the lowest amount needed of any essential nutrient at just 2.4 mcg
per day or 2.8 mcg per day for pregnant or lactating women. Even better news,
your body stores A LOT of Vitamin B12 (2-5
mg) in the liver and
elsewhere; about 3 years worth! [3] This means it would take you years to
develop a B12 deficiency if you completely stopped consuming B12 right now. So really, you do not need to consume a lot of
B12 or even very frequently to stay in the safe zone.
(Caveat, those with absorption issues may need to consume more to overcome malabsorption.
Fortified
foods actually result in a more consistent absorption of B12 than from
animal proteins because you do not need to engage a pathway involving acid production in the stomach that releases the B12 from animal protein. In some populations, such as the elderly, you may see a decreased bioavailability (how much you can actually absorb) for animal protein.)
Here is a list of the common sources of B12
(and look at just how much is contained in some of these!)
Remember, you only need about 2.5 mcg per day and you can store the rest for years!
Selected Food Sources of Vitamin B12
| Food |
Micrograms (mcg)
per serving |
|
| Clams, cooked, 3 ounces | 84.1 |
|
| Liver, beef, cooked, 3 ounces | 70.7 |
|
| Breakfast cereals, fortified with 100% of the DV for vitamin B12, 1 serving | 6.0 |
|
| Trout, rainbow, wild, cooked, 3 ounces | 5.4 |
|
| Salmon, sockeye, cooked, 3 ounces | 4.8 |
|
| Trout, rainbow, farmed, cooked, 3 ounces | 3.5 |
|
| Tuna fish, light, canned in water, 3 ounces | 2.5 |
|
| Cheeseburger, double patty and bun, 1 sandwich | 2.1 |
|
| Haddock, cooked, 3 ounces | 1.8 |
|
| Breakfast cereals, fortified with 25% of the DV for vitamin B12, 1 serving | 1.5 |
|
| Beef, top sirloin, broiled, 3 ounces | 1.4 |
|
| Milk, low-fat, 1 cup | 1.2 |
|
| Yogurt, fruit, low-fat, 8 ounces | 1.1 |
|
| Cheese, Swiss, 1 ounce | 0.9 |
|
| Beef taco, 1 soft taco | 0.9 |
|
| Ham, cured, roasted, 3 ounces | 0.6 |
|
| Egg, whole, hard boiled, 1 large | 0.6 |
|
| Chicken, breast meat, roasted, 3 ounces | 0.3 |
|
[U.S. Department of Agriculture, Agricultural Research Service. 2011.
USDA National Nutrient Database for Standard Reference, Release 24.
Nutrient Data Laboratory Home Page,
http://www.ars.usda.gov/ba/bhnrc/ndl.]
So basically all you really need is a good clam linguine 4 times a year and you got your B12, baby!
I now deem clams a superfood.
Notice that seafood is in the top of the chart. Liver is up there as well because that's where animals store B12.....oooohhh!
Ok, vegetarian and vegan friends. I didn't forget you.
There are common foods fortified with B12 such as breakfast cereals, nondairy milks (soy and rice milk, etc),
soy protein foods, like vegetarian burgers, and some margarines. Look on the nutrition facts to see if it has been fortified with B12.
So what's the big deal if I don't get enough Vitamin B12?
It's a huge deal!
Vitamin B12 plays a vital role in cell synthesis (creation). If B12 is not present, a cell simply cannot divide and create new cells. This results in anemia (lack of red blood cells), neuropathy (usually a loss of sensation/feeling touch) and fertility just to name a few. Physically you would be weak, pale, lethargic, etc.....not fun.
These deficiencies are actually not as much associated with not consuming enough vitamin B12 but it is more commonly an issue with its complex absorption as is what you see in the elderly population.
The elderly have decreased stomach acid productions which is a necessary component of B12 absorption to release the B12 from protein. This deficiency in B12 has been linked to decreased cognitive function (thought processing) and dementia possibly due to increased levels of homocysteine in the blood. This, as you can imagine, is difficult to study.
Elderly are also more likely to be malnourished possibly contributing to eating less fortified foods so their intake may also be low. Supplements may be the best option for some populations.
Here are some of the most common causes of Vitamin B12 deficiency
1- Inadequate dietary intake especially among vegans, infants of vegan mothers and malnourished vegetarians.
2- Genetic errors of Vitamin B12 metabolism
3- Inadequate absorption due to auto-immune antibodies to intrinsic factor, a cofactor needed in the absorption of B12. This is also called Pernicious Anemia. This most commonly affects elderly and those of Northern European decent.
*This is the most common cause of severe B12 deficiency*
So we can see that inadequate dietary intake is not actually what causes the worst kind of B12 deficiency across the nation but it does have a higher prevalence in the vegan and vegetarian population. So it is something to be somewhat concerned about since these trends can actually be seen. If these statistics were based on only a vegetarian or vegan population, I would guess that inadequate dietary intake might be the most common cause of B12 deficiency.
I have a special interest in maternal/fetal health.
So how does all this relate to pregnancy and outcomes for the fetus?
Infants exclusively breastfed by vegan mothers have very often exhibited severe B12 deficiency. You can't see it at first but after a few months the infant starts to exhibit symptoms of decreased growth, lethargy, weakness and pallor from anemia which can develop into decreased movement and coma. Remember that vitamin B12 plays a big role in the creation of new cells, which occurs quite rapidly in a normal developing infant.
Treatment with B12 resulted in rapid improvement, but many times the children did not return to baseline function and had lower IQs. This is also seen in new mothers in developing countries that had a diet low in animal products.
So basically what it comes down to is this.
We need Vitamin B12.
How you get it doesn't really seem to matter unless you are elderly, then you may benefit from fortified foods or supplements. However you choose to obtain it, whether from animal products or fortified foods, you need it to keep you and your babies safe and functioning properly.
If you want to get your B12 the most "natural" way, then at least a small amount of animal product is going to be your best bet. You do not have to obtain it from animal products but make sure you are getting enough fortified foods or supplements.
I personally want to obtain my nutrition the most natural and whole way possible (also known as Clean Eating) so I am going to be a proponent of a small amount of animal meat (clams) as a way to load up on Vitamin B12.
The investigation continues as to whether or not meat contributes to health problems such as cancer so as of right now, clams seem to be a good happy medium as far as Vit B12 goes.
The Verve Body Diet will now include a small amount of clams (or beef liver ...blegh) just a handful of times per year.
Wait,
wait,
wait!
You forgot the most important question about B vitamins!
"Where did the 'other' B vitamins go?!"
You know. B4, B8, B10 and B11?
Well, as the B vitamins were being discovered, numbers were given to all the compounds they thought to be B vitamins....and then they realized "Oops! These aren't B vitamins... some aren't even vitamins at all!"
Now you know.
References:
1- J Oncol Pharm Pract. 2006 Dec;12(4):237-9
2- Nutrition & Dietetics 2007; 64 (Suppl. 4): S120–S125
3- Up to Date 2012;
Physiology of vitamin B12 and folic acid deficiency,
S Schrier, K Motil, et al